ea0022p3 | Adrenal | ECE2010
Giordano Roberta
, Falorni Alberto
, Mandrile Giorgia
, Gioachino Daniela
, Balbo Marcella
, Berardelli Rita
, Karamouzis Ioannis
, Marinazzo Elisa
, Picu Andreea
, Marzotti Stefania
, Romagnoli Serena
, Ghigo Ezio
, Arvat Emanuela
Object: In Addisons disease (AD), although glucocorticoid (GC) replacement is essential for health and, indeed, life, several studies showed that conventional GCs doses are involved in metabolic and cardiovascular alterations observed in this disease. As the effects of GCs are mediated by the glucocorticoid receptor (GR), encoded by NR3C1 gene, different polymorphisms in the NR3C1 gene have been linked to altered glucocorticoid sensitivity in general population as well a...